Must-Have Peptide Serums For Healthy Skin

So Very Sciency.

Last updated on: 03/27/2024 at 3:52 pm

All our recommended products and services are independently selected with our readers in mind. If you decide to click on any links we include, we may receive compensation at no extra cost to you. Explore Further


best peptide serums

Photo: Imaxtree


As we get older, our bodies don’t quite work the same way they once did, and many of the internal changes we go through show up on our skin. Fortunately, there’s an entire industry dedicated to helping maintain our skin’s youthfulness and even repair damage that’s been done over the years. While not all anti-aging products will deliver on what they promise, peptide serums are one anti-aging skincare product that can really give your skin a boost.


Peptides act as cell-communicating agents that improve firmness, texture, and other visible signs of aging such as fine lines. By stimulating your cells to improve their functionality, the best peptide serums can both repair damage that’s already done and prevent future damage.


Of the best peptide serums out there, those using Matrixyl or copper peptide top the list. We’ve broken down this top 10 into the best of both worlds: the 5 best copper peptide serums and the 5 best Matrixyl peptide serums. But first, let’s learn a bit more about what peptides are and how they work.




Peptides are short chains of amino acids. These chains of amino acids serve as building blocks to the skin’s structure. Peptides are what make up things like collagen, elastin, and keratin. And, if you know anything about skincare, you know that these proteins are responsible for your skin’s strength, texture, and elasticity – aka, the things that make skin look healthy, supple and youthful.


The main cause of skin aging is the loss of these proteins. From about the mid-20s to early 30s, our body begins to slow the production of collagen, elastin, and keratin by about 1% per year. By the age of 40, production drops dramatically and our skin really begins to show our years. To make matters worse, it’s about this time that years of sun exposure, environmental pollutants, stress, and other skin damage begin to settle in.


So, what’s the answer? Using products that stimulate collagen, elastin, and keratin is one – and peptide serums are really good at that.


The reason why peptides work so harmoniously with your skin is that we naturally produce our own peptides, so your body recognizes them easily. Peptides created in a lab are so close to that which our body produces naturally, that they are able to act as cell-communicating agents. That is, they tell your skin to create proteins like collagen, elastin, and keratin. As your body begins to produce those proteins in greater amounts, it gets stronger, plumper, and more youthful-looking.


When combined with other, complementary ingredients, peptide serums can have additional beneficial properties. They can strengthen the skin barrier, improve moisture retention, soothe the skin, and even begin to repair damage.




Matrixyl is one of the most popular peptides out there, and there are 3 forms of it: Matrixyl, Matrixyl 3000, and Matrixyl Synthe’6. All three are what’s known as lipopeptides – that is, they mix amino acids and fatty acids. As peptides, they are capable of targeting collagen synthesis to improve elasticity, wrinkles, sagging, and uneven skin tone. As fatty acids, they also carry additional benefits.


For example, while Matrixyl increases hydration levels, Matrixyl 3000 has the added benefit of inhibiting glycation damage, and Matrixyl Synthe’6 can repair even some of the most damaged skin and deepest lines.


Below are our picks for some Matrixyl peptide serums to consider:


ClarityRX Get Fit Multi-Peptide Healthy Skin Serum ClarityRX Get Fit Multi-Peptide Healthy Skin Serum $105

ClairtyRX fills their products with only concentrated, pharmaceutical-grade ingredients. In this cult-favorite peptide serum, Matryxl Synthe’6 meets 5 other full-strength peptides (including Matrixyl 3000, SNAP-8 & Argireline), to combat fine lines as well as uneven skin tone. Get Fit is also formulated with hyaluronic acid, which aids your skin in maintaining hydration levels by binding moisture to its surface.



NCN Professional Matrixyl Serum

NCN Professional Skincare Multi-Active Matrixyl Serum $50

With the anti-aging properties of all three Matrixyl variations, this peptide serum is a powerful solution for skin elasticity, firmness, and preventing glycation damage. It rapidly reduces both the volume and depth of fine lines and wrinkles – so crows feet and forehead lines are dramatically smoothed out. And to lock in moisture while all that work is being done, the formula also contains hyaluronic acid.



Olay Regenerist Regenerating Serum

Olay Regenerist Regenerating Serum $19.29

When we’re combatting deep wrinkles, we need a serum that penetrates the topmost layers of the skin. This Regenerating Serum uses Matrixyl to do exactly that – going as deep as ten layers to plump your skin and fill those lines from the origins. Available in scented and fragrance-free variations, this lightweight and non-greasy serum is perfect for all skin types and especially useful for those who are looking for smoother skin.




Jan Marini Age Intervention Peptide Extreme Jan Marini Age Intervention Peptide Extreme $102

A face serum that’s beneficial for all skin types, Jan Marini brings us a fan-favorite formula featuring the most concentrated blend of proprietary peptides you can get. Matrixyl, Myristolyl Pentapeptide-8, Myristoyl Tetrapeptide-KA2, and Myristoyl Pentapeptide-11, work together to assist your skin in producing more than sufficient quantities of both collagen and elastin. At the same time, the formula contains antioxidants like grape seed and meadowfoam oil that fight free radical damage and anti-irritants such as shea butter that reduce inflammation and redness.



The Ordinary Matrxyl 10% + HA

The Ordinary Matrxyl 10% + HA $15.60

This cost-effective serum has a combined concentration of 10% Matrixyl 3000 and Matrixyl Synthe’6 which is delivered to your skin’s surface via ultra-hydrating hyaluronic acid. The alcohol and silicone-free formula has a pH between 5 and 6 to restore balance to your skin while reducing the visible signs of aging – especially stubborn wrinkles. Alternatively consider The Ordinary’s  extremely popular “Buffet” Serum ($14.80). The formula contains a multitude of peptides including Matrixyl 3000, Matrixyl Synthe’6 and Syn-Ake peptides.



HydroPeptide Face Lift Advanced Ultra-Light MoisturizerHydroPeptide HydroStem+6 Stem Cell Antioxidant Serum $160

Though on the pricier side of things Hydropeptide’s extremely popular serum has developed a cult following. Through a blend of multiple skin-beneficial ingredients inclusive of 9 peptides, Hyaluronic Acid, and several powerful antioxidants like Bearberry extract as well as Green Tea Extract, the gluten-free formula lifts, hydrates, and boosts the skin’s luminosity.  Other key ingredients to look out for include a reparative copper peptide and moisturizing Panthenol (Vitamin B5).



Timeless Skincare Matrxyl Synthe’6 Serum

Timeless Skincare Matrxyl Synthe’6 Serum $20

Timeless’s popular formula combines moisture-boosting Hyaluronic Acid with Matrixyl Synthe’ 6, (Palmitoyl Tripeptide-38), the form of the peptide that is known for its ability to rebuild the skin’s structure and combat wrinkles. The cruelty-free serum dries fast and leaves the skin without any greasy feeling.


Replenix AE SerumMatrixyl: Replenix AE Dermal Restructuring Therapy $95

The goals of Replenix AE Dermal Restructuring Therapy are to reverse fine lines and wrinkles, deliver a boost of hydration, and improve the function of the skin’s natural barrier. So how did they think to do that? By blending natural green tea polyphenols with a mega-dose of other anti-aging ingredients. Fine lines and wrinkles are blurred through new collagen growth supported by peptides, hydration is sealed in as your skin barrier gets stronger with hyaluronic acid, and retinol works on your whole complexion for younger looking skin.



Peter Thomas Roth Wrinkle Resist Serum

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum $125

Suitable for use on your face and neck – the two areas that show aging the most – the Peptide 21 Wrinkle Resist Serum syndicates some of the newest and most innovative ingredients for fighting fine lines and wrinkles. That includes 16 peptides, 5 neuropeptides, 2 gamma proteins, along with an infusion of hyaluronic acid, squalene, and vitamins A, C, and E. You’ll benefit from a visible reduction in wrinkles, fine lines, and expression lines, as well as improvements in everything from elasticity to skin texture.




Mario Badescu Super Peptide Serum

Mario Badescu Super Peptide Serum $45

Intended for use after cleansing and toning but before moisturizer, this serum is something entirely its own. Four drops every morning is a large enough dose to start restoring plump and youthful skin. Each drop is powered by peptides, sodium hyaluronate complex for absorption and hydration, as well as a refreshing and conditioning blend of botanicals – something we don’t often see in peptide formulas but that we’d like to see more of, to be honest.



Jack Black Protein Booster Skin Serum

Jack Black Protein Booster Skin Serum $62

Because women aren’t the one’s concerned with looking older, Jack Black has developed the ProSeries collection. These anti-aging products that cater specifically to men combine the latest and greatest in anti-aging ingredients with PureScience Technology to create highly active formulas. The peptide serum of the collection can be used alone or along with your favorite moisturizer. Either way, it promises to minimize the visible signs of aging and keep your skin healthy.



Copper is a mineral that’s found naturally in our saliva, blood plasma, and in our skin tissue. As a skincare ingredient, it’s been around for more than 40 years – and anything that’s been around for that long holds some weight with us.


Copper peptide is typically a combination of three amino acids that come in 1% concentrations in skin care products. Research has shown that this anti-aging ingredient does more than combat the visible signs of aged skin. Beyond reducing the appearance of fine lines and wrinkles by boosting collagen production, copper peptides can help with inflammation, dehydration, skin texture, and free radical damage.


Keep reading to find out more about the best copper peptide serums out there.


Replenix Pure Hydration Hyaluronic Acid SerumReplenix Pure Hydration Hyaluronic Acid Serum $84

Through a combination of multiple skin-beneficial ingredients, Replenix’s hydrating serum improves the way the skin looks and feels. Key ingredients include the powerful antioxidant Green Tea,  Copper PCA, and Hyaluronic Acid to boost hydration levels as well as Palmitoyl Tripeptide-28 (a peptide) to boost collagen production.



NCN Professional skincare copper peptides moisturizer is one of the best on the market.

NCN Pro Skincare GHK-Cu Copper Peptide Formula 1 $73

GHK-Cu is so potent that you’ll have to ease it into your skincare routine. But once you do, you’ll notice that damaged skin heals faster, collagen is produced in higher quantities, and inflammation is significantly reduced. So when you’re looking to repair the damage that’s already occurred and strengthen your skin without added irritation, grab this copper peptide amino complex.



NEOVA Night Therapy

Neova Night Therapy $85

Blending botanical and clinical ingredients, this popular night serum gives you the best of both worlds. Ceramides, hyaluronic acid, and GHK copper peptides battle hyperpigmentation, sun damage, and free radical damage, while omega fatty acids, vitamin e, and antioxidants like green tea improve your hydration levels and restore your skin’s brightness and radiance. It’s so powerful that a once-a-day treatment is more than enough to get your skin back to beautiful.



NuFACE Booster Copper Complex Infusion SerumNuface Booster Copper Complex Serum $84

This form of copper peptide reduces enlarged pores and works with panthenol (B) and aloe to support your skin barrier and its ability to improve suppleness and resiliency. It’s full of antioxidizing and soothing vitamins A, C, E, and F as well as the rare botanicals Gotu Kola and coneflower. A healthy choice for those who avoid parabens, alcohol, and fragrances.



iS CLINICAL Super Serum Advance+

iS CLINICAL Super Serum Advance+ $148

They don’t call this a super serum for nothing. With 15% l-ascorbic acid (i.e. vitamin C) and copper tripeptide, this clinically-validated advanced serum will help you say goodbye to under-eye puffiness and creepy skin, as well as dull skin tone. Use it twice per day to help repair damaged or scarred skin and protect your face from free radical damage.



Drunk Elephant Protini Polypeptide CreamDrunk Elephant Protini Polypeptide Cream $85

Drunk Elephant’s Peptide formula may not be a serum but it is a fan favorite. The gel-cream combines a variety of peptides including Copper Palmitoyl Heptapeptide-14 (a copper peptide) with a number of skin-beneficial ingredients like nutrient-rich Marula seed oil, antioxidants like Water Lily extract as well as hydrating Sodium hyaluronate (salt version of Hyaluronic Acid).  Like all the rest of the product range, the light moisturizer is made without known skin irritants like fragrance and sulfates.




If you’re new to the world of peptide serums, no worries. Choose one of our recommendations above, and make sure to keep these considerations in mind while you use them.


  • Peptides do their best work when they’re formulated in a leave-on product, like a serum. While you might find peptides in a face wash, that doesn’t give these mini-miracle ingredients enough time to absorb into your skin and do their job. With that said, moisturizers and creams are other great ways to incorporate peptides.
  • Keeping in mind that peptides need to be absorbed into the skin in order to communicate with your cells, make sure you’re using your peptide serum after you wash your face but before you moisturize. Moisturizers can create an occlusive barrier that hinders the peptides from reaching your skin’s surface and getting fully absorbed.
  • Because they mimic something our body already produces, peptides are considered safe for all skin types, including sensitive skin. But, like any new product you’re incorporating into your skincare routine, you may want to start slowly so your skin can build tolerance. Start your peptide serum 2-3 times per week, working up to every day, twice a day. And although they’re marketed as anti-aging skincare, there’s really no right or wrong age to start using them.
  • Don’t mix peptides with alpha-hydroxy acids (AHAs) because they can reduce the effectiveness of peptide serums. If you want to continue using your AHA product while using peptide serum, use one in the morning and one at night.
  • Do use peptides with ingredients like niacinamide, hyaluronic acid, antioxidants and vitamin C. These ingredients will empower your peptides as well as add soothing and hydrating qualities.


To learn more about Matrixyl and Copper Peptides and how to use them correctly, check out our Matrixyl article here or our Copper Peptides article here.




There are many peptide serums out there and even more skincare products that utilize this beneficial, skin-repairing, age-defying ingredient. But, in our humble opinion, the best peptide serums are those that harness the power of Matrixyl or copper peptides.

A good general rule of thumb: for a brighter complexion and deep hydration, consider Matrixyl. And when you need to repair damage and soothe inflammation, find yourself one of these five copper peptide serums. And when you’re looking for all of the above, alternate your products so you can have your cake and eat it, too.


Published on: 11/14/2018 Last updated on: 03/27/2024

Trish Keatings is Lead Writer at The Youthist since 2018. Her writing career began after graduating from the University of Saskatchewan with a Master of Arts Degree, where she focused on Political Studies. Trish is currently traveling the world and fills her free hours with yoga, meditation, wellness workshops, and eating her way through new cuisines. With a passion for all things beauty and skin, she is particularly inspired by holistic and ayurvedic approaches to health and personal care. A student of these philosophies herself, she enthusiastically explores her passions through her writing and finds no greater joy than taking her readers along with her.

Exploring the best eyebrow trimmers available.

Why You Need An Eyebrow Trimmer

Rose Water For Hair

best setting powder for dry skin

Editor-Approved Setting Powders for Dry Skin