The Best Of Vitamin C Serums

So Bright It Hurts.

Last updated on: 01/28/2024 at 8:18 pm

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best vitamin c serum for acne

Photo: Imaxtree


Vitamin C is much more than a boost to your immune system during cold and flu season. This antioxidant, like so many others, is a powerhouse skincare ingredient that rejuvenates your skin.


It tackles everything from hyperpigmentation and breakouts to free radical damage and scarring. Regardless of your skin concern (or even your skin type), Vitamin C is a safe ingredient that’s proven to improve your complexion and help stave away the visible signs of aging.


Though you can get Vitamin C through many of the foods you eat, using a topical Vitamin C serum is one of the most effective approaches to maximize all of its benefits.




So, what is a Vitamin C serum?


Put simply, it’s a serum wherein Vitamin C is the active ingredient. Kind of self-explanatory, no?


These serums usually combine Vitamin C with other skin-beneficial ingredients to fight free radicals, calm inflammation, soothe irritation, boost the production of collagen, brighten and even skin tone, and protect against harmful UV rays.


We’ll get into all of the benefits of the best Vitamin C serums a little later but, for now, let’s talk abou the five most common forms of Vitamin C found in cosmetic products: L-Ascorbic acid, Magnesium Ascorbyl Phosphate, Sodium Ascorbyl Phosphate, Calcium Ascorbate, and Ascorbyl Palmitate.




This derivative of Vitamin C is the most common form you’ll find in skincare products and it also has the most research behind it. L-ascorbic acid is prized for its ability to protect against UV rays, increase collagen and elastin levels, improve skin tone and texture, and reduce dark spots and discoloration.


On the downside, L-Ascorbic acid oxidizes quickly when it’s exposed to air and light. Meaning, it has to be stored with utmost care. It can also cause irritation and redness at high concentrations. If you have sensitive skin, look for formulas with 10-15%.




This form of Vitamin C will also boost collagen and elastin, brighten and even skin tone, and has positive effects on hyperpigmentation. Although less is known about it, we do know that it’s more stable than L-Ascorbic acid and won’t rapidly oxidize when exposed to light and air. It’s also gentler on your skin and can be used in concentrations ranging anywhere from 1-20%.




A combination of ascorbic acid, phosphate, and salt, this is a less-active form of ascorbic acid that’s perfect for those with sensitive skin. Like Magnesium Ascorbyl Phosphate, it’s also more stable for use in skincare. It’s a great antioxidant that improves your skin’s defence against environmental stressors and it also boosts collagen production, evens skin tone, and caries antimicrobial benefits.




Because it’s got calcium in it, this form of Vitamin C has benefits for bones, cartilage, and tissue that you just won’t find in the others. Besides that superpower, it’s also a formidable antioxidant that promotes the production of collagen to reduce the appearance of fine lines and wrinkles as well as eliminate dark spots. This is an excellent option for mature skin.




One of the mildest forms of Vitamin C, it still packs an anti-aging punch – and it does so without irritating sensitive skin. Ascorbyl palmitate is able to penetrate the deepest layers of skin tissue to stimulate collagen synthesis, and that provides visible improvements to skin texture and tone.


However, like ascorbic acid, this form of Vitamin C can break down when it’s exposed to heat and oxygen. So it’s imperative that it’s packaged and stored correctly.





Vitamin C Serums treat a variety of skin concerns, but here are the main ones:




Vitamin C doesn’t treat acne directly, but it does remedy the consequences of this skin concern. In fact, there are a couple of ways Vitamin C for acne works. Mainly, it reduces redness and inflammation as well as helps fade post-breakout scarring.




Your immune system has its own ways of dealing with acne – the problem is, sometimes this process results in redness that can make your skin look just as bad as it does during a breakout.


Leukotrienes are the inflammatory chemicals produced by your immune system to kill acne-causing bacteria. But acne-causing bacteria have a decoy system that causes those chemicals to redirect towards the skin, causing it to turn red.


Vitamin C works to calm the immune system rather than stimulate it, preventing the destruction of healthy skin and redirecting its efforts toward the bacteria in your pores. In addition, Vitamin C strengthens the lining of your capillaries (microscopic blood vessels that bring oxygen and nutrients to your skin). The redness of breakouts is usually generated at this layer of the dermis. So, by strengthening your capillaries with Vitamin C for acne, you minimize leaks of bright red blood vessels.




Luckily enough, many of us grow out of our acne stage. But that doesn’t help the scars that it tends to leave behind. Vitamin C helps with the body’s natural healing process, so it can boost the healing process for acne scars and other blemishes quickly and effectively. It also boosts cell regeneration and the formation of new skin, which will reduce the appearance of any scars.




Free radicals are molecules produced by your body as it breaks down food, but they’re also triggered by things in our environment such as UV rays, pollution, and tobacco smoke. When you don’t have a good balance between antioxidants and free radicals, the latter can attack your skin and cause fine lines, wrinkles, dark spots, sagging skin, dullness, and uneven skin tone.


Vitamin C is one of the best antioxidants there is. It breaks down free radicals, converting them into harmless compounds and also clears toxins from your skin.




Hyperpigmentation comes in many forms: sun spots, age spots, brown-ish marks or ‘the mask of pregnancy’. All of these manifestations are caused by accumulations of melanin and they make you look older because your skin tone and texture appear (and in some cases are) uneven and dull.


UV exposure is the most common cause of discoloration. UV rays stimulate pigment cells in our skin and cause our bodies to produce melanin. But there are, of course, other reasons as well. Heat, hormones from birth control or during pregnancy, and injury to the skin are all contributors to dark spots. And, while all skin tones can experience hyperpigmentation in its various forms, people of Asian, Mediterranean, and African descent tend to be more sensitive to developing discoloration.


Vitamin C gently exfoliates your skin and encourages cell regeneration. By allowing dead skin to shed and be replaced by new skin, hyperpigmentation tends to fade. Vitamin C also blocks the enzyme known as tyrosinase which is a key component in the production of melanin. By blocking tyrosinase you prevent discoloration from occurring, leading to a brighter and more even skin tone. As we’ve already mentioned, the best vitamin C serums will also help speed up the healing process, taking care of any injury-caused hyperpigmentation, and also treats redness that may be contributing to an uneven skin tone.


When using Vitamin C for hyperpigmentation, one must practice patience because most products will take at least 4 weeks to start working. You also can’t expect to use a vitamin C serum for hyperpigmentation while continuing to bask in the sun’s rays – you should be staying out of the sun and wearing a strong broad-spectrum sunscreen or you’ll be counteracting any benefits of the treatment.




Vitamin C serums have an answer for everything skin-related. By promoting the production of essential proteins like collagen and elastin, the building blocks of your skin, Vitamin C helps prevent and treat fine lines and wrinkles. As we all know by now, our body produces less and less of these proteins as we age, but boosting their levels helps treat their appearance and also prevents their formation.




A topical Vitamin C serum is pretty effective for protecting your skin from harmful UVA and UVB rays. While it shouldn’t replace the regular use of a good broad-spectrum sunscreen, it is an antioxidant that strengthens your skin and its ability to repel damaging environmental factors. And if you’re one of us “day-walkers” (aka pale people), Vitamin C can also help heal sunburns as part of its healing properties.



Vitamin C isn’t the only vitamin with skin-beneficial properties. Check out our guide on the most effective topical vitamins to learn about other antioxidants that can help strengthen and protect your skin.




Two heads are better than one and that’s true in skincare, too. Combining Vitamin C with other skin-beneficial ingredients can increase its efficacy and help you target more than one skin concern at a time. Below we’ve outlined two things you should consider adding to your Vitamin C treatment.




Like Vitamin C, this vitamin is an antioxidant. It increases the protective properties of vitamin C because it too fights free radicals and protects against harmful UV rays. Vitamin E can also help balance the production of sebum, ensuring your skin is properly hydrated from the outside in. When combined with Vitamin C, it boosts your body’s ability to heal and fight inflammation. Look for formulas that contain 15% Vitamin C and 1% vitamin E for best results.




Found in the seeds of fruits as well as in some vegetables, nuts, and grains, Ferulic Acid is a very powerful natural antioxidant. Ferulic acid fights free radicals to a greater degree than the aforementioned and is able to destroy several different types of free radicals: ‘superoxide’, ‘hydroxyl radical’, and ‘nitric oxide’. This is probably one of the best natural tools for fighting wrinkles, especially when used with Vitamin C and E. Combining 15% Vitamin C, 1% Vitamin E and 0.5% Ferulic Acid makes Vitamin C 8x more effective. Look for a serum with these concentrations, or close to, to get the most out of your Vitamin C treatment.






100% Pure Vitamin C Serum

100% Pure Vitamin C Serum $40

Along with  Vitamin C (in one of its gentlest forms of Magnesium Ascorbyl Phosphate), you’ll find the plant extracts Grape Seed and Apple extract as well as nourishing Vitamin E in this formula. The light-weight serums’ active ingredients are protected from the elements since they are housed in opaque packaging.




Cosmetic Skin Solution Vitamin C+E SerumCosmetic Skin Solution Vitamin C+E Serum $39.50

Cosmetic Skin Solutions’ Formula combines 3 powerful antioxidants: 15% Vitamin C (Ascorbic acid), 1% Vitamin E and 0.1% Ferulic Acid to fight free radical damage and brighten and treat uneven skin tone. The oil-free serum is produced fresh each week and is made without parabens and is also cruelty-free.



Skin Medica Vitamin C+E Complex Age DefenseSkin Medica Vitamin C+E Complex Age Defense $102

Skin Medica’s serum combines 2 forms of stabilized Vitamin C and Vitamin E to maximize potential rejuvenation benefits. Other key benefits of the fragrance-free formula and that the brand doesn’t test its products on animals.



Paula’s Choice, Super Antioxidant Serum

Paula’s Choice Super Antioxidant Serum $38

Paul’s Choice’s highly-rated serum goes beyond the standard combination of Vitamin C, E and Ferulic acid by packing in a number of other skin-beneficial ingredients inclusive of a stabilized form of a peptide (Palmitoyl Tripeptide-5) that helps the way the skin functions, the intriguingSuperoxide Dismutase known for its rejuvenating benefits as well as even plant extracts from the likes of Green Tea among other. Other key benefits of the fragrance-free serum are that it is non-irritating and never tested on animals.




Skinceuticals C E Ferulic Combination Antioxidant TreatmentSkinceuticals C E Ferulic Combination Antioxidant Treatment $165

Skinceutical’s formula contains the exact right combinations of Vitamin C and E and Ferulic Acid (15%, 1%, and 0.5% ferulic acid respectively) to target skin concerns like hyperpigmentation, free radical as well as acne-prevention.  As an added bonus, this serum combines VItamin B5 (Panthenol) with Hyaluronic Acid to provide the skin with increased hydration.



the best Vitamin C E Ferulic Acid Serum for anti-agingDrunk Elephant C-Firma Day Serum ($80)

With an appropriate pH level of 3.3-3.5, Drunk Elephant’s serum is non-irritating and has all the advantages of Vitamins C and E combined with Ferulic Acid as well as multiple other skin-beneficial ingredients. These include plant extracts from the likes of Pumpkin and Pomegranate that help as well as Sodium Hyaluronate (salt form of Hyaluronic Acid) plus Murula Oil to help with hydration and moisture.

If you’re in a Martha Stewart mood, why not try a DIY vitamin C serum? If you’d like to try making your own serum, check out our guide on how to make a simple DIY Vitamin C Serum.

Alternatively, if you’re looking for a natural route check out our rundown of the best organic and natural Vitamin C serums.



The best Vitamin C serums can be used twice per day. At the very least, we recommend applying it after your morning cleanser and wearing it throughout the day. It’s best to apply the serum underneath your broad-spectrum sunscreen because, as you now know, it boosts the power of the sun protection agents in your sunscreen and wards off the damaging effects of UV rays.




With Vitamin C serums, refrigeration is a MUST. These serums oxidize quickly when they’re exposed to both light and air. By keeping it in a cool, dark place (like a refrigerator), you’ll help extend the shelf life.


Disclaimer: oxidized vitamin C isn’t dangerous, it just won’t be effective.





You can check the serum’s pH levels every few weeks to determine how fresh it is. This is especially important when making your own serum or when using L-Ascorbic acid.


You can check the pH with pH strips. For serums using L-Ascorbic acid, the pH should be between 2.5 and 3.5. For serums using Magnesium Ascorbyl Phosphate, the pH should fall between 6.0 and 7.0.


If you notice that the serum is yellow/brown (and it was originally clear), it’s already oxidizing. You can make the decision to keep or throw it out, but keep in mind the oxidized Vitamin C is not as effective.





Vitamin C isn’t supposed to oxidize when it’s well protected from the elements. As long as you’re not exposing the bottle to heat or sunlight, you can keep Vitamin C serums for between 3 and 6 months before they need to be discarded.





In terms of how long they take to work, you can see results as quickly as 4 weeks if you’re using a Vitamin C serum regularly, but you’re more than likely going to have to wait at least 12 to realize its full potential. Keep in mind that the period may be longer if you need to get your skin used to the serum first – Vitamin C can sensitize skin so you should take your time working up to a daily application.





Vitamin C is a natural solution to many of the most common skin concerns. It works well, especially when combined with other ingredients, but we’d be remiss not to mention that there are other effective solutions that target the same concerns, and we think they’re worth your consideration.




We don’t recommend physical exfoliation (i.e. using a granular product to rub away and remove dead skin). Instead, look into chemical peels are chemical exfoliants. These treat hyperpigmentation as well as the visible signs of aging like fine lines and wrinkles.

A chemical peel will literally peel away and shed the top layers of the dermis. In so doing, these cosmetic procedures boost cell turnover, reveal fresh layers of skin and, in turn, help fade hyperpigmentation.  For all the rejuvenating benefits of chemical peels have a look at our in-depth article.




Retinol is a derivative of Vitamin A. It’s a topical solution for combating fine lines and wrinkles, improving skin texture and tone, increasing skin firmness and reducing breakouts. With minimal long-term side effects and fairly quick results, Retinol is a powerful antioxidant with a host of benefits for your skin.


There’s a lot to know about retinol and its different forms. Our guide on how retinol improves skin will help you navigate everything you need to know about this form of vitamin A and what it can do for your skin.




The sun is one of the main contributors to premature aging. UV rays and the damage they cause manifest in uneven skin tone as well as fine lines and wrinkles. By protecting your skin with sunscreen, you create a barrier between your delicate skin and the sun, minimizing any prospective damage it can cause.


It’s not enough to pick up a sunscreen from the shelf and think you’re protected. There are good ingredients and bad sun protection ingredients.  We can help you figure all of that out with our guide to understanding your sunscreen.





Vitamin C serums are an excellent addition to your skincare routine on their own or, even more so, when combined with other powerful antioxidants. Not only does it act as a treatment for discoloration, acne, and the damage caused by free radicals, but it’s also a great preventative treatment so you can stop the signs of aging before they start. With Vitamin C in your arsenal, you can be sure your skin is protected and looks the best that it can be.

Trish Keatings
Published on: 11/19/2018 Last updated on: 01/28/2024

Trish Keatings is Lead Writer at The Youthist since 2018. Her writing career began after graduating from the University of Saskatchewan with a Master of Arts Degree, where she focused on Political Studies. Trish is currently traveling the world and fills her free hours with yoga, meditation, wellness workshops, and eating her way through new cuisines. With a passion for all things beauty and skin, she is particularly inspired by holistic and ayurvedic approaches to health and personal care. A student of these philosophies herself, she enthusiastically explores her passions through her writing and finds no greater joy than taking her readers along with her.

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